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Stephen R. Perrin, Jr.
Ph.D. Graduate Student Department of Biomedical Engineering University of Cincinnati | |
EDUCATION Currently pursuing Ph.D. in Biomedical Engineering University of Cincinnati, Cincinnati, Ohio Estimated Graduate Date: 2012 RESEARCH INTERESTS My specific research plans include testing the thrombolytic efficacy of rt-PA loaded ELIP in a porcine clot model in vivo. In addition, I plan to quantify the penetration of exogenous rt-PA into the intracerebral clots using fluorescent labeling and a histological technique. Tiukinhoy-Laing et al. (Thrombosis Research, 2007) have shown the lytic activity of rt-PA after release from ELIP relative to free rt-PA, in a porcine clot model in vitro. Although enhanced penetration of the drug into the clot is a positive and beneficial bioeffect, a potential negative bioeffect would be the enhanced transport of this drug across the vascular endothelium in the brain. By tracking the fluorescently labeled rt-PA in vivo, we will be able to gauge the potential for negative side effects in this clinically important membrane transport phenomenon. CONTACT Department of Biomedical Engineering University of Cincinnati 231 Albert Sabin Way, MSB, 6163 Cincinnati, Ohio, 45267-0586 Phone: (513) 558-5505 Email: perrinsr@email.uc.edu | ||